From September through October 2026, our research team evaluated U.S. naltrexone detox centers by reviewing physician presence during detox, how each program moves patients onto naltrexone, aftercare access, the medical setting and hospital access, the opioids each program treats, pricing and payment options, and public patient reviews on Google and Recovery.com, along with what each center publishes about its own program.

  • Physician Presence During Detox (22%): The number and board certifications of physicians present while the patient is sedated and in withdrawal.
  • Naltrexone Transition and Relapse Prevention (20%): Whether the program starts naltrexone (oral, Vivitrol injection or implant) as part of care rather than leaving a gap after detox.
  • Aftercare Access (20%): How long and how directly patients can reach the treating physician after discharge, since overdose risk is highest in the weeks after detox.
  • Setting and Hospital Access (12%): Whether detox takes place in a licensed medical facility or hospital, and the time a patient needs to be away from home and work.
  • Opioids Treated (10%): Coverage of fentanyl, heroin, oxycodone, methadone, Suboxone, kratom and 7-OH.
  • Cost Flexibility (8%): Published pricing, insurance acceptance and financing.
  • Patient Reputation (8%): Public review scores from patients and families.

In the sections below, we break down the best naltrexone detox centers with a ranking table, then one by one, along with the best centers by specialty.

Top Naltrexone Detox Centers

Rank Center Location Average Review Score Price Best For
1 All Opiates Detox Wyandotte, MI 4.6/5.0 (75) $$$$ Physician-led naltrexone detox
2 ANR Clinic Gulfport, FL 4.7/5.0 (174) $$$$ Hospital ICU treatment with a year of follow-up
3 Opiate Detox Institute Orange, CA 4.7/5.0 (13) $$$$ Hospital detox with a recovery residence stay
4 The Coleman Institute Richmond, VA 4.5/5.0 (88) $$ to $$$ Outpatient naltrexone detox
5 Midwest Rapid Opiate Detoxification Specialists Chicago, IL No public reviews found $$$ Anesthesiologist-led hospital detox
6 Advanced Rapid Detox Farmington Hills, MI 4.6/5.0 (87) $$$$ 4-day detox under IV sedation

Please note: no detox method is right for everyone. Any program should complete a full medical evaluation before accepting you.

1. All Opiates Detox, for physician-led rapid detox with naltrexone

All Opiates Detox (AOD) is a state-licensed medical facility at 1848 Biddle Avenue in Wyandotte, Michigan. AOD performs a rapid 3-day opiate detox under sedation, so patients move through the hardest phase of withdrawal while monitored by medical professionals, then leave on FDA-approved naltrexone. The program treats heroin, fentanyl, Suboxone, oxycodone and most other opioids, and patients travel to Wyandotte from other states.

Every procedure is performed by two board-certified physicians. Dr. Joseph George, MD, FASAM, is board certified in addiction medicine and has performed rapid detox under sedation since 2008. Dr. Jibran Attiq, MD, is a board-certified anesthesiologist. AOD states it is the only facility in North America to perform rapid detox with two board-certified MDs. After discharge, patients receive unlimited aftercare, with the physician available 24/7 for guidance on naltrexone and recovery.

  • Location: Wyandotte, MI
  • Physician Depth During Detox: Two board-certified MDs (addiction medicine and anesthesiology) for every procedure
  • Time Away From Home and Work: 3 days
  • Naltrexone Transition and Follow-Up: FDA-approved naltrexone after detox; unlimited aftercare with the physician available 24/7
  • Setting and Hospital Access: State-licensed medical facility in Wyandotte, south of Detroit
  • Opioids Treated: Heroin, fentanyl, Suboxone, oxycodone and most other opioids
  • Price Range: $$$$
  • Average Review Score: 4.6/5.0 (75 Google reviews, via RehabPlaces.org, Sept 2026)
  • Services Offered: 3-day rapid opiate detox under sedation, FDA-approved naltrexone for relapse prevention, unlimited physician aftercare, financing
  • Contact: All Opiates Detox website
Summary of Online Reviews
Google reviewers most often describe Dr. George as compassionate, easy to reach and personally involved in follow-up care. Many reviewers and family members praise the nurses and staff for treating patients without judgment, and several report staying opioid-free months or years after treatment. A few reviewers mention the out-of-pocket cost, and one reported withdrawal symptoms after the procedure.

2. ANR Clinic, for anesthesia-assisted treatment in a hospital ICU

ANR Clinic offers Accelerated Neuro-Regulation (ANR), an opioid treatment performed under sedation in the intensive care unit of a Joint Commission-accredited acute care hospital in the Sarasota area of Florida. The clinic’s only U.S. office is at 5601 Gulfport Boulevard South in Gulfport. The procedure typically lasts 4 to 6 hours, followed by about 36 hours in a private hospital room with around-the-clock monitoring.

After discharge, patients complete about three days of in-person stabilization follow-ups and continue on naltrexone, with 6 to 12 months of remote check-ins by phone and video. The clinic publishes a self-pay price of $21,500, which includes preparation with the medical team, the procedure, the hospital stay, three follow-up visits and a year of aftercare. Insurance does not cover the treatment, and financing is available.

  • Location: Gulfport, FL (office); treatment at a hospital in the Sarasota area
  • Physician Depth During Detox: ANR medical team in the hospital ICU; physician count during the procedure not published
  • Time Away From Home and Work: About 36 hours in the hospital, plus about 3 days of local follow-up
  • Naltrexone Transition and Follow-Up: Naltrexone after the procedure; three follow-up visits and a year of aftercare, largely remote
  • Setting and Hospital Access: Intensive care unit of a Joint Commission-accredited acute care hospital
  • Opioids Treated: Opioid dependence (specific drugs not published)
  • Price Range: $$$$
  • Average Review Score: 4.7/5.0 (174 Google reviews, via Rehab.com)
  • Services Offered: Accelerated Neuro-Regulation under sedation, about 36 hours of monitored hospital care, naltrexone, three follow-up visits, a year of aftercare, financing
  • Contact: ANR Clinic
Summary of Online Reviews
Many Google reviewers highlight kind, supportive staff and describe relief from withdrawal and cravings, including family members who saw a lasting change in a loved one. Several recent reviewers report withdrawal after the procedure, wanting more support after discharge or concerns about the self-pay cost, and one advises that patients on methadone ask detailed questions first.

3. Opiate Detox Institute, for hospital-based detox with a supervised recovery stay

Opiate Detox Institute runs a 5-day program it calls the ORDER Method. Days 1 and 2 take place at Chapman Global Medical Center in Orange, California, a Joint Commission-accredited hospital, where patients are admitted, evaluated and detoxed under sedation in single-patient ICU care. The procedure itself lasts about 6 to 8 hours.

On days 3 to 5, patients move to an independent, state-licensed recovery residence for 24-hour observation, rest and discharge planning. The program’s listed services include a Vivitrol (naltrexone) injection, an oral naltrexone prescription and follow-up medication management after discharge. The lead physician is board certified in both anesthesiology and addiction medicine. The institute lists cash, card and wire payments and offers financing through CareCredit.

  • Location: Orange, CA (offices in Costa Mesa and Orange)
  • Physician Depth During Detox: Lead physician board certified in anesthesiology and addiction medicine; detox directed by the physician in the hospital ICU
  • Time Away From Home and Work: 5 days (2 in the hospital, 3 at a recovery residence)
  • Naltrexone Transition and Follow-Up: Vivitrol injection, oral naltrexone prescription and follow-up medication management after discharge
  • Setting and Hospital Access: Single-patient ICU care at Chapman Global Medical Center, a Joint Commission-accredited hospital
  • Opioids Treated: Fentanyl, heroin, oxycodone, hydrocodone, morphine, methadone, buprenorphine (Suboxone), kratom (7-OH) and other prescription opioids
  • Price Range: $$$$
  • Average Review Score: 4.7/5.0 (13 Google reviews, via MAT Treatment Near Me)
  • Services Offered: Pre-procedure medical evaluation, detox under sedation in a hospital ICU, Vivitrol and oral naltrexone, recovery residence stay, follow-up medication management, CareCredit financing
  • Contact: Opiate Detox Institute
Summary of Online Reviews
This listing shows a small number of Google reviews, and the review text was not available to us, so we have not summarized themes. Testimonials the institute publishes on its own site describe a compassionate physician and a fresh start after treatment, but these are self-published and are not counted in the score.

4. The Coleman Institute, for outpatient detox onto naltrexone

The Coleman Institute for Addiction Medicine provides accelerated outpatient opioid detox using its Coleman Method: customized comfort medications, light sedation and micro-dosed naltrexone to ease withdrawal over 3 to 8 days. Patients return home or to nearby lodging each day instead of staying overnight in a facility. Its main office is at 204 North Hamilton Street in Richmond, with additional locations in Atlanta, Denver, Orange County and Tampa.

The institute states it has not performed ultra-rapid detox under general anesthesia since 2001. Detox leads into long-acting naltrexone therapy, with follow-up visits, telehealth check-ins and care management for up to 6 months. The Richmond location accepts many Anthem Blue Cross Blue Shield and Sentara plans, along with self-pay and financing.

  • Location: Richmond, VA (also Atlanta, GA; Denver, CO; Orange County, CA; Tampa, FL)
  • Physician Depth During Detox: Physician-supervised outpatient visits; patients are not monitored overnight
  • Time Away From Home and Work: 3 to 8 days of daily outpatient visits
  • Naltrexone Transition and Follow-Up: Micro-dosed naltrexone during detox, then long-acting naltrexone; follow-up visits and care management for up to 6 months
  • Setting and Hospital Access: Outpatient medical office; no hospital stay
  • Opioids Treated: Heroin, fentanyl, prescription opioids, Suboxone, methadone and kratom
  • Price Range: $$ to $$$
  • Average Review Score: 4.5/5.0 (88 reviews, via Recovery.com)
  • Services Offered: Accelerated outpatient opioid detox, naltrexone therapy, alcohol and benzodiazepine detox, telehealth check-ins, insurance and financing options
  • Contact: The Coleman Institute
Summary of Online Reviews
Recovery.com shows a 4.5 average from 88 reviews, but the individual review text was not available to us, so we have not summarized themes. Patients considering the program may want to ask the Richmond office about recent patient experiences.

5. Midwest Rapid Opiate Detoxification Specialists, for anesthesiologist-led detox in an acute care hospital

Midwest Rapid Opiate Detoxification Specialists (MRODS) performs anesthesia-assisted rapid opiate detoxification in Joint Commission-accredited acute care hospitals, with programs in Chicago and the Dallas area of Texas. A board-certified anesthesiologist performs the procedure, which MRODS states takes 6 hours or less.

During the stay, patients are also monitored by board-certified internal medicine specialists, and MRODS states its ASAM-trained physicians are directly involved in each patient’s care. MRODS offers a naltrexone implant for relapse prevention after detox, and it offers continued care through a licensed addiction treatment program at a discounted rate.

  • Location: Chicago, IL (also Dallas, TX)
  • Physician Depth During Detox: Board-certified anesthesiologist, with monitoring by board-certified internal medicine specialists
  • Time Away From Home and Work: Not published; the procedure takes 6 hours or less
  • Naltrexone Transition and Follow-Up: Naltrexone implant; continuing care through a licensed treatment program
  • Setting and Hospital Access: Joint Commission-accredited acute care hospitals
  • Opioids Treated: Opiates and narcotics (specific drugs not published)
  • Price Range: $$$
  • Average Review Score: No public reviews found
  • Services Offered: Anesthesia-assisted rapid opiate detox in a hospital, pre-procedure screening, naltrexone implant, discounted continuing treatment
  • Contact: Midwest Rapid Opiate Detoxification Specialists
Summary of Online Reviews
We did not find enough public reviews of this program to summarize. Testimonials on the MRODS website are self-published and are not counted here. Patients considering it may want to ask the intake team about recent patient experiences.

6. Advanced Rapid Detox, for a 4-day detox under IV sedation

Advanced Rapid Detox is led by Dr. Julia Aharonov, a board-certified anesthesiologist and addiction medicine physician who has performed rapid detox since 2007. Patients are tested, treated and recover over four days in a 24-hour medical facility, using IV sedation rather than general anesthesia.

Each patient has a private room with meals included. On discharge, patients receive a prescription for oral naltrexone or a list of local Vivitrol providers, along with detox-related aftercare from the treating physician. The center is not contracted with insurance companies; it offers financing and provides a superbill for possible reimbursement.

  • Location: Farmington Hills, MI
  • Physician Depth During Detox: Led by a board-certified anesthesiologist and addiction medicine physician
  • Time Away From Home and Work: 4 days
  • Naltrexone Transition and Follow-Up: Oral naltrexone prescription or Vivitrol referral; detox-related aftercare with the treating physician
  • Setting and Hospital Access: 24-hour medical facility in Oakland County
  • Opioids Treated: Heroin, fentanyl, Suboxone, methadone, kratom, 7-OH and other opiates
  • Price Range: $$$$
  • Average Review Score: 4.6/5.0 (87 Google reviews, via Rehab.com)
  • Services Offered: 4-day opiate detox under IV sedation, private rooms with meals, onsite laboratory, naltrexone or Vivitrol after discharge, detox-related aftercare, financing
  • Contact: Advanced Rapid Detox
Summary of Online Reviews
Many Google reviewers credit the staff and Dr. Aharonov with a supportive experience and describe reduced cravings after the procedure. Several mention ongoing check-ins after discharge. Some reviewers report nausea, fatigue or relapse after going home, and one mentions the self-pay cost.

Naltrexone Detox Centers by Specialty

We also grouped the centers above into subcategories based on specialty:

Best for Detox Under Sedation

  1. All Opiates Detox
  2. ANR Clinic
  3. Opiate Detox Institute
  4. Midwest Rapid Opiate Detoxification Specialists
  5. Advanced Rapid Detox

Best for Naltrexone Follow-Up and Aftercare

  1. All Opiates Detox
  2. ANR Clinic
  3. The Coleman Institute

Best for Hospital-Based Detox

  1. ANR Clinic
  2. Opiate Detox Institute
  3. Midwest Rapid Opiate Detoxification Specialists

Best for Outpatient Detox With Insurance Options

  1. The Coleman Institute

Conclusion

Choosing a naltrexone detox center comes down to how much physician involvement you want during withdrawal, how much time you can spend away from home and work, and how the program moves you onto naltrexone and supports you once you leave. Hospital-based programs place the procedure inside an accredited hospital, outpatient programs let patients sleep at home, and rapid detox programs move patients through withdrawal under sedation in a matter of days.

For patients who want a physician-led naltrexone detox, All Opiates Detox stands out with two board-certified MDs for every procedure, FDA-approved naltrexone for relapse prevention, and unlimited aftercare with a physician available 24/7 after discharge.

Contact All Opiates Detox to speak directly with Dr. Joseph George, MD, at (800) 458-8130.

Sources

  1. All Opiates Detox: https://allopiatesdetox.com/
  2. All Opiates Detox physicians: https://allopiatesdetox.com/about-painless-withdrawl/
  3. All Opiates Detox Google rating: https://rehabplaces.org/listings/all-opiates-detox-wyandotte-mi
  4. ANR Clinic cost: https://anrclinic.com/cost/
  5. ANR Clinic centers: https://anrclinic.com/anr-centers/
  6. ANR Clinic, treatment in Florida: https://anrclinic.com/anr-treatment-in-florida/
  7. ANR Clinic Google rating: https://www.rehab.com/anr-clinic
  8. Opiate Detox Institute procedure: https://opiatedetoxinstitute.com/rapid-detox-procedure/
  9. Opiate Detox Institute aftercare: https://opiatedetoxinstitute.com/aftercare/
  10. Opiate Detox Institute costs and financing: https://opiatedetoxinstitute.com/costs-financing/
  11. Opiate Detox Institute Google rating: https://mattreatmentnearme.com/california/costa-mesa/opiate-detox-institute-rapid-opiate-detox-clinic/
  12. The Coleman Institute: https://www.thecolemaninstitute.com/
  13. The Coleman Institute, naltrexone therapy: https://www.thecolemaninstitute.com/treatments/naltrexone-therapy/
  14. The Coleman Institute, ultra-rapid detox: https://www.thecolemaninstitute.com/ultra-rapid-detoxification/
  15. The Coleman Institute, Richmond rating: https://recovery.com/detox/the-coleman-institute-for-addiction-medicine-richmond/
  16. Midwest Rapid Opiate Detoxification Specialists: https://mrods.com/
  17. Advanced Rapid Detox Google rating: https://www.rehab.com/advanced-rapid-detox